Nature Biotechnology
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MOSAIC is a high-throughput gene synthesis method driven by hybridization (the self-assembly of complementary oligonucleotides during thermal annealing) instead of enzymatic processing. By using the full capacity of microchip-based oligonucleotide synthesis, MOSAIC enables the parallel production of over 1,000 distinct gene fragments and mutant libraries in a simple \u2018one-pot\u2019 reaction.<\/p>\n
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