{"id":2749,"date":"2026-08-03T03:31:45","date_gmt":"2026-08-03T03:31:45","guid":{"rendered":"https:\/\/futureknowledge.in\/?p=2749"},"modified":"2026-08-03T03:31:45","modified_gmt":"2026-08-03T03:31:45","slug":"an-activity-resistance-trade-off-constrains-enzyme-evolution","status":"publish","type":"post","link":"https:\/\/futureknowledge.in\/?p=2749","title":{"rendered":"An activity\u2013resistance trade-off constrains enzyme evolution"},"content":{"rendered":"<p>Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. &lt;br\/&gt;SignificanceAntibiotic producers must be resistant to the toxins that they produce, but how such self-resistance develops is a mystery. The mycophenolic acid (MPA) biosynthetic gene cluster (BGC) encodes a resistant variant of the MPA target inosine &#8230;<\/p>\n<p><em>Source: <a href='https:\/\/www.pnas.org\/doi\/abs\/10.1073\/pnas.2602068123?af=R' target='_blank'>Read the original article on www.pnas.org<\/a><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. &lt;br\/&gt;SignificanceAntibiotic producers must be resistant to the toxins that they produce, but how such self-resistance develops is a mystery. The mycophenolic acid (MPA) biosynthetic gene cluster (BGC) encodes a resistant variant of the MPA target inosine &#8230; Source: Read the original article [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2750,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-2749","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-technology"],"_links":{"self":[{"href":"https:\/\/futureknowledge.in\/index.php?rest_route=\/wp\/v2\/posts\/2749","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/futureknowledge.in\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/futureknowledge.in\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/futureknowledge.in\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/futureknowledge.in\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2749"}],"version-history":[{"count":0,"href":"https:\/\/futureknowledge.in\/index.php?rest_route=\/wp\/v2\/posts\/2749\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/futureknowledge.in\/index.php?rest_route=\/wp\/v2\/media\/2750"}],"wp:attachment":[{"href":"https:\/\/futureknowledge.in\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2749"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/futureknowledge.in\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2749"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/futureknowledge.in\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2749"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}