HUWE1 targets mitochondria via RMC1 to promote neurodevelopment

Proceedings of the National Academy of Sciences, Volume 123, Issue 30, July 2026. <br/>SignificanceMutations in HUWE1 are a recurrent cause of X-linked intellectual disability, yet most studies have focused on catalytic defects and the consequences for nuclear substrates. The present work identifies a mitochondrial pathway that is … Source: Read the original article on www.pnas.org